Move the USB receiver to a different USB port (front of system vs. back) or try a short USB extension cable to move the USB receiver.
or
There could be radio interference. Move the receiver away from other electronic devises (e.g. monitor, speakers, radio, etc.).
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What do the different lights on my mouse mean?
The 3 orange lights indicate the battery level. The blue light flashes when trying to connect to the USB receiver. The blue light is steady when used on the desk or in the air.